Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory drugs versus benzydamine hydrochloride oral rinses after mandibular third molar extraction: a pilot study
Goswami Devalina, Jain Gaurav, Mohod Mangesh, Baidya Dalim Kumar, Bhutia Ongkila, Roychoudhury Ajoy,
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( Goswami Devalina ) - Indial Institute of Medical Sciences Department of Anesthesiology, Pain Medicine and Critical Care
( Jain Gaurav ) - Indial Institute of Medical Sciences Department of Oral and Maxillofacial Surgery
( Mohod Mangesh ) - Indial Institute of Medical Sciences Department of Oral and Maxillofacial Surgery
( Baidya Dalim Kumar ) - Indial Institute of Medical Sciences Department of Anesthesiology, Pain Medicine and Critical Care
( Bhutia Ongkila ) - Indial Institute of Medical Sciences Department of Oral and Maxillofacial Surgery
( Roychoudhury Ajoy ) - Indial Institute of Medical Sciences Department of Oral and Maxillofacial Surgery
Abstract
Background: Third molar extraction is associated with considerable pain and discomfort, which is mostly managed with oral analgesic medication. We assessed the analgesic effect of benzydamine hydrochloride, a topical analgesic oral rinse, for controlling postoperative pain following third molar extraction.
Methods: A randomized controlled trial was conducted in 40 patients divided into two groups, for extraction of fully erupted third molar. Groups A received benzydamine hydrochloride mouthwash and group B received normal saline gargle with oral ibuprofen and paracetamol. Oral ibuprofen and paracetamol was the rescue analgesic drug in group A. Patients were evaluated on the 3rd and 7th post-operative days (POD) for pain using the visual analogue score (VAS), trismus, total number of analgesics consumed, and satisfaction level of patients.
Results: The VAS in groups A and B on POD3 and POD7 was 4.55 ± 2.54 and 3.95 ± 1.8, and 1.2 ± 1.64 and 0.95 ± 1.14, respectively and was statistically insignificant. The number of analgesics consumed in groups A and B on POD3 (5.25 ± 2.22 and 6.05 ± 2.43) was not statistically different from that consumed on POD7 (9.15 ± 5.93 and 10.65 ± 6.46). The p values for trismus on POD3 and POD7 were 0.609 and 0.490, respectively and those for patient satisfaction level on POD3 and POD7 were 0.283 and 0.217, respectively.
Conclusions: Benzydamine hydrochloride oral rinses do not significantly reduce intake of oral analgesics and are inadequate for pain relief following mandibular third molar extraction.
키워드
Benzydamine Hydrochloride; Third Molar; Tooth Extraction; Topical Application
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